Diabetes in Cardiovascular Disease: A Companion to by Darren K. McGuire PDF

By Darren K. McGuire

ISBN-10: 1455754188

ISBN-13: 9781455754182

Diabetes in Cardiovascular Disease is a present, specialist source targeting the advanced demanding situations of delivering cardiovascular care to sufferers with diabetes. Designed as a significant other to Braunwald's center Disease, this interdisciplinary scientific reference e-book bridges the gap among the cardiology and endocrinology groups of scientists and care services, and highlights the rising medical and scientific topics which are appropriate for cardiologists, diabetologists/endocrinologists, and the prolonged diabetes care team.

Access crucial assurance of simple and medical sciences, complemented through an improved concentrate on epidemiology, behavioral sciences, wellbeing and fitness coverage, and disparities in future health care.
Take benefit of a format that follows that of the well known and across the world well-known Braunwald's middle Disease.
Review the simplest on hand medical facts and pragmatic recommendations for the prevention and administration of cardiovascular issues of diabetes; national/societal intervention thoughts to lower the growing to be incidence of diabetes; and the present pathophysiological knowing of cardiovascular comorbidities in sufferers with diabetes.
Consult this identify in your favourite e-reader, behavior swift searches, and modify font sizes for optimum readability.

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Additional info for Diabetes in Cardiovascular Disease: A Companion to Braunwald's Heart Disease

Sample text

A reduced capacity of insulin-dependent translocation of GLUT-4 to the plasma membrane is observed as a consequence of insulin resistance. Concerning the crosstalk between various tissues, the adipose tissue and adipocytes contribute to the development of insulin resistance by producing and secreting mediators such as adipokines and cytokines that act on the muscle and other target tissues of insulin action. The visceral adipose tissue is now seen as an endocrine organ with respect to special functions concerning the activation and secretion of numerous hormones and cytokines that mediate insulin resistance and chronic inflammation.

By contrast, when lipotoxicity is present, hepatic glucose production increases and lipids are released, with an atherogenic profile. Dysregulated hepatokine production also contributes to the development of metabolic diseases. The important heptokines are listed in Table 2-3, and Figure 2-5 shows a schematic diagram of the TABLE 2-3 Function of Important Hepatokines In Vitro and In Vivo EFFECTS In Vitro or Animal Studies In Humans Angiopoietin-related protein 6 Energy expenditure " Obesity # NAFLD # Insulin resistance # Insulin resistance " Fetuin A Obesity $/" Insulin resistance " Subclinical inflammation " Obesity $ NAFLD " Insulin resistance " Subclinical inflammation " T2DM " CVD " FGF 21 Energy expenditure " Insulin resistance # Beta cell survival " Obesity " NAFLD " Insulin resistance " IGFs and IGFBPs Insulin resistance $/"/# Insulin resistance "/# Selenoprotein P Insulin resistance " Insulin resistance " Subclinical inflammation " Sex hormonebinding globulin Sex hormone bioavailability " Sex hormone signaling " Obesity # NAFLD # Insulin resistance # Subclinical inflammation # T2DM # Cardiovascular disease # Hepatokine CVD ¼ Cardiovascular disease; T2DM ¼ type 2 diabetes mellitus.

When hepatic detoxification processes are active, storage of lipids in the liver is not associated with metabolic diseases. By contrast, when lipotoxicity is present, hepatic glucose production increases and lipids are released, with an atherogenic profile. Dysregulated hepatokine production also contributes to the development of metabolic diseases. The important heptokines are listed in Table 2-3, and Figure 2-5 shows a schematic diagram of the TABLE 2-3 Function of Important Hepatokines In Vitro and In Vivo EFFECTS In Vitro or Animal Studies In Humans Angiopoietin-related protein 6 Energy expenditure " Obesity # NAFLD # Insulin resistance # Insulin resistance " Fetuin A Obesity $/" Insulin resistance " Subclinical inflammation " Obesity $ NAFLD " Insulin resistance " Subclinical inflammation " T2DM " CVD " FGF 21 Energy expenditure " Insulin resistance # Beta cell survival " Obesity " NAFLD " Insulin resistance " IGFs and IGFBPs Insulin resistance $/"/# Insulin resistance "/# Selenoprotein P Insulin resistance " Insulin resistance " Subclinical inflammation " Sex hormonebinding globulin Sex hormone bioavailability " Sex hormone signaling " Obesity # NAFLD # Insulin resistance # Subclinical inflammation # T2DM # Cardiovascular disease # Hepatokine CVD ¼ Cardiovascular disease; T2DM ¼ type 2 diabetes mellitus.

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Diabetes in Cardiovascular Disease: A Companion to Braunwald's Heart Disease by Darren K. McGuire


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