Download e-book for kindle: Complex Structure and Dynamics of the Heart by Philip Bittihn

By Philip Bittihn

ISBN-10: 3319122312

ISBN-13: 9783319122311

ISBN-10: 3319122320

ISBN-13: 9783319122328

This award-winning thesis investigates the mechanisms underlying cardiac arrhythmia improvement and termination from a wholly new standpoint. via viewing the guts as a posh procedure, the writer makes use of theoretical instruments from nonlinear dynamics mixed with numerical simulations and experiments to accomplish insights into the connection among its constitution and dynamics, thereby paving the way in which in the direction of leading edge low-energy defibrillation suggestions. The paintings tackles, between different issues: the impact of substrate heterogeneity at the spatial-temporal dynamics of cardiac arrhythmias and ways that vulnerable pulsed electrical fields can be utilized to manage those dynamics in heterogeneous cardiac tissue. The long term imaginative and prescient of this study is to exchange the present technique of employing painful and infrequently tissue destructive electrical surprise – at present the one trustworthy strategy to terminate life-threatening traumatic inflammation – through a extra sophisticated yet both powerful intervention. The ebook maps out a couple of promising learn instructions for biophysicists and scientific researchers engaged on the origins and therapy of cardiac arrhythmias.

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Roden, D. M. (1998). Mechanisms and management of proarrhythmia. The American Journal of Cardiology, 82, 49I–57I. 64. , & Kalman, J. M. (2011). Proarrhythmia following prior pulmonary vein isolation: What is the mechanism? Journal of Cardiovascular Electrophysiology, 23, 884–886. 65. Hilleman, D. , & Bauman, A. L. (2001). Role of antiarrhythmic therapy in patients at risk for sudden cardiac death: An evidence-based review. Pharmacotherapy, 21, 556–575. References 21 66. Schwab, J. O. (2012). Antitachycardia pacing to terminate ventricular tachyarrhythmia: New insights into how to reduce painful implantable cardioverter defibrillator shocks.

1991). One-dimensional model of cardiac defibrillation. Medical & Biological Engineering & Computing, 29, 465–469. 89. Gillis, A. , Fast, V. , & Kléber, A. G. (1996). Spatial changes in transmembrane potential during extracellular electrical shocks in cultured monolayers of neonatal rat ventricular myocytes. Circulation Research, 79, 676–690. 90. , & Tung, L. (1997). A generalized activating function for predicting virtual electrodes in cardiac tissue. Biophysical Journal, 73, 1410–1423. 91. , & Vepa, K.

Secondly, the properties of the Lyapunov spectra determined in the first part shall be used to characterize more complex scenarios involving multiple spirals and heterogeneous media. It will be shown that heterogeneities can have ambivalent effects on the complexity of spiral wave or chaotic activity. In Sect. 2, the interaction of electric fields with boundaries of cardiac tissue is investigated. As indicated in Sect. 6, a number of studies have aimed at determining the mechanisms that cause bulk depolarization during electric-field stimulation and thus lead to the success of conventional defibrillation.

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Complex Structure and Dynamics of the Heart by Philip Bittihn

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