Download e-book for kindle: Cardiac Arrhythmias: The Management of Atrial Fibrillation by P. J. Schwartz (auth.), Prof. Dr. Ronald W. F. Campbell,

By P. J. Schwartz (auth.), Prof. Dr. Ronald W. F. Campbell, Prof. Dr. Michiel J. Janse (eds.)

ISBN-10: 3540555889

ISBN-13: 9783540555889

ISBN-10: 3662304929

ISBN-13: 9783662304921

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Extra info for Cardiac Arrhythmias: The Management of Atrial Fibrillation

Example text

Force of contraction (Fe) was recorded at the apex of the preload active tension curve via the inductive force displacement transducer in conjunction with a HeUige frequency carrier preamplifier. The transmembrane potential was detected intracellularly by the use of 10 to 20-MQ glass microelectrodes filled with KCI 3 mol/I. The signals were led off by means of a voltage follower with input capacitance compensation. For the determination of maximal upstroke velocity of the action potential, dVidt was obtained by analogue differentiation.

APD was increased in the recording depicted on the left side, whereas an decrease in APD was observed in the other preparation. Fe was decreased in both preparations. b Influence of frequency of stimulation on dV/dt max obtained und er control conditions and in the presence of quinidine. Under control conditions, only at high frequencies of stimulation was a decrease in dV/dt max observed (frequency-dependent block). The depressive effect on dV/dt max was enhanced in the presence of quinidine 3 Ilmol/l.

In: Zipes DP, Jalife J (eds) Cardia electrophysiology - from cell to bedside. Saunders, Philadelphia, pp 548-559 Campbell TJ (1983) Kinetics of onset of rate-dependent effects of Class I antiarrhythmie drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification. Cardiovasc Res 17:344 Costard A, Liem LB, Franz MR (1989) Rate dependent effect of quinidine, mexiletine, and their combination on postrepolarization refractoriness in vivo.

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Cardiac Arrhythmias: The Management of Atrial Fibrillation by P. J. Schwartz (auth.), Prof. Dr. Ronald W. F. Campbell, Prof. Dr. Michiel J. Janse (eds.)


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