Biomarker by T. Khan PDF

By T. Khan

ISBN-10: 9535105779

ISBN-13: 9789535105770

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2. The role of epigenetics in cancer Epigenetics alterations have been growing as a promisor tool to understand cancer development, for better clinical therapy management, to identify new cancer biomarkers, which can help in monitoring disease evolution. It is known that epigenetics corresponds basically by two majority modifications: DNA methylation and chromatin modifications. DNA methylation is a covalent modification of the cytosine ring 5’ position of a CpG dinucleotide, whereby a methyl group is deposited on carbon 5 of that ring using Sadenosyl methionine as a methyl donor.

With the delineation of the characteristics that drive the biological phenotype of MDS, new drugs introduced in the treatment of this disease have shown a great therapeutic potential, such as the hypomethylant agents, called methyltransferase inhibitors (IMT). The representatives of this class include azacitidine (5-azacytidine) and decitabine (5-aza 2 'deoxycytidine). Both are incorporated into DNA and then irreversibly bind and inhibit the action of DNA methyltransferase. This interaction results initially in a semi-methylated DNA.

Thus, being able to use these techniques needs some skills in order to choose the correct statistical test. 2 Parametric and nonparametric tests Combining the notion of a frequency distribution (descriptive statistics) and probability, we can explain what means a probability distribution. A probability distribution is a table or a graph that describes the probability of an event occurs. It describes what probably will happen instead of describing what really happened. A probability distribution can be discrete or continuous.

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Biomarker by T. Khan


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