Download e-book for iPad: Biological and Medical Research in Space: An Overview of by David Moore
By David Moore
This booklet is aimed toward the extensive neighborhood of scientists whose study may benefit from attention of gravitational and area biology as one other size of environmental interference on their paintings. you will need to tension the various molecular, mobile and physiological mechanisms, in all varieties of lifestyles, that are encouraged through, or finally depending on, gravity or radiation. The publication brings jointly effects from house flight and ground-based experiments within the a number of lifestyles technological know-how disciplines that are scattered within the literature and sometimes released in resources no longer simply on hand to the final medical neighborhood. a few of the effects acquired are it appears contradictory of predictions of classical hypotheses and therefore deserve common cognizance. The presentation emphasizes, a entire and demanding assessment of accessible info, aiming not just to enhance entry to the knowledge, yet to remark additionally on its credibility and position it in right context. This well timed overview also will profit these engaged in layout, overview and execution of existence technological know-how experiments in space.
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Extra resources for Biological and Medical Research in Space: An Overview of Life Sciences Research in Microgravity
Hunzinger from Cogoli et al. 1988. e. display of a large number of pseudopodia, in the 0 x g samples (Cogoli et al. 1988; Cogoli et al. 1993). Finally, as shown in Fig. 6, transmission and scanning electronmicrographs of cultures flown in Spacelab SLS-l, in which cells were attached to micro carrier beads, revealed that (i) cells had a strong interaction with the substratum; and (ii) that attached cells did not deteriorate in micro gravity as free floating cells did (Bechler et al. 1992; Cogoli et al.
The hypothesis that changes in membrane function and, consequently, in the availability of membrane glycoproteins to Con A may occur in microgravity, was tested in two experiments conducted on sounding rockets (Cogoli, M. et al. 1990). The instruments provided automatic injection of fluorescence-labelled Con A, followed by fixation at given times with paraformaldehyde during seven minutes in microgravity. Both experiments showed that binding of the mitogen to the membrane was not affected, only a slight delay of patching and capping was observed.
1 Background Two questions have always intrigued researchers in gravitational biology: first, do shape and morphology of a cell change in micro gravity? Second, are free floating cells which are not provided with locomotion organelles like cilia, capable of autonomous movements in microgravity? Biophysical calculations of the forces necessary to alter the shape of a cell show that gravity is not strong enough to influence cell shape. This means that the flattening of a cell sedimented to the bottom a cell culture flask at 1 x g is not due to gravitational forces but rather to the spreading of the cell on the surface.
Biological and Medical Research in Space: An Overview of Life Sciences Research in Microgravity by David Moore