Antitargets: Prediction and Prevention of Drug Side Effects by Roy J. Vaz, Thomas Klabunde, Raimund Mannhold, Hugo Kubinyi, PDF

By Roy J. Vaz, Thomas Klabunde, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

ISBN-10: 3527318216

ISBN-13: 9783527318216

This practice-oriented guide surveys present wisdom at the prediction and prevention of difficult drug reactions on the topic of off-target job of small molecule medicines. it's specified in collating the present methods right into a unmarried resource, and contains a number of hugely instructive case reviews which may be used as instructions on the right way to enhance drug improvement initiatives. With its huge part on ADME-related results, this is often key wisdom for each drug developer.

Show description

Read or Download Antitargets: Prediction and Prevention of Drug Side Effects PDF

Best industrial & technical books

Basic principles and calculations in chemical engineering by David M. Himmelblau, James B. Riggs PDF

''Over the earlier decade the sector of chemical engineering has broadened considerably, encompassing quite a lot of matters. in spite of the fact that, the elemental underlying rules have remained an identical. to assist readers maintain velocity, this quantity maintains to provide a complete creation to the rules and strategies utilized in the sector of chemical, petroleum, and environmental engineering.

New PDF release: Introduction to Electrochemical Science and Engineering

As a result of the expanding call for for strength new release and the constrained nature of fossil fuels, new tasks for strength improvement in line with electrochemical strength conversion structures are arising around the globe. creation to Electrochemical technology and Engineering describes the elemental operational ideas for a few starting to be electrochemical engineering-related applied sciences, together with gasoline cells, electrolyzers, and stream batteries.

James G. Speight's The chemistry and technology of coal PDF

The call for for coal use (for electrical energy new release) and coal items, fairly liquid fuels and chemical feedstocks, is expanding during the global. conventional markets reminiscent of North the United States and Europe are experiencing a gentle elevate admired while rising Asian markets, corresponding to India and China, are witnessing a swift surge admired for fresh liquid fuels.

Download PDF by Ron Darby, Raj P. Chhabra: Chemical Engineering Fluid Mechanics, Third Edition

This publication presents readers with the most up-tp-date, exact, and sensible fluid mechanics comparable functions that the practising BS point engineer wishes this present day within the chemical and similar industries, as well as a primary figuring out of those purposes established upon sound primary uncomplicated medical ideas.

Extra info for Antitargets: Prediction and Prevention of Drug Side Effects

Example text

The New England Journal of Medicine, 333, 1600–1607. P. Discontinuation of Trancopal (chlormezanone). fda. htm, last accessed on 16th December 2003. Pharmainformation Appetitzügler. html, last accessed on 15th December 2002. FDA FDA Announces Withdrawal of Fenfluramine and Dexphenfluramine (Fen-Phen). htm, last accessed on 5th March 2003. J. A. (2001) The underreporting of results and possible mechanisms of “negative” drug trials in patients with chronic heart failure. International Journal of Cardiology, 80, 19–27.

It was also prescribed to pregnant women as an antiemetic for morning sickness. By the end of 1961, it was found that thalidomide caused severe teratogenic effects, with strong fetal malformations like phocomelia (shortened or absent arms and legs). The drug was quickly withdrawn from the market, but in between 5000 and 12 000 deformed babies were born worldwide, with an unknown number of aborted fetuses. It was found that as little as a single dose of 50 mg, taken between day 35 and 49 after the last menstrual period, could produce the characteristic birth defects.

R. (1988) Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964–1985). British Journal of Clinical Pharmacology, 25, 387–396. 5 Kennedy, T. (1997) Managing the drug discovery/development interface. Drug Discovery Today, 2, 436–444. 6 WHO Amineptine (INN). doc, last accessed on 24th November 2003. 7 Amineptine (Survector): the Smart Tricyclic Antidepressant. BLTC. www. com, last accessed on 9th January 2007. 8 BIAM Amineptine Chlorhydrate. BIAM. org/www/Sub1826. html#Present, last accessed on 9th January 2007.

Download PDF sample

Antitargets: Prediction and Prevention of Drug Side Effects by Roy J. Vaz, Thomas Klabunde, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

by Richard

Rated 4.43 of 5 – based on 3 votes