Antitargets: Prediction and Prevention of Drug Side Effects by Roy J. Vaz, Thomas Klabunde, Raimund Mannhold, Hugo Kubinyi, PDF

By Roy J. Vaz, Thomas Klabunde, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

ISBN-10: 3527318216

ISBN-13: 9783527318216

This practice-oriented guide surveys present wisdom at the prediction and prevention of difficult drug reactions on the topic of off-target job of small molecule medicines. it's specified in collating the present methods right into a unmarried resource, and contains a number of hugely instructive case reviews which may be used as instructions on the right way to enhance drug improvement initiatives. With its huge part on ADME-related results, this is often key wisdom for each drug developer.

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Extra info for Antitargets: Prediction and Prevention of Drug Side Effects

Example text

The New England Journal of Medicine, 333, 1600–1607. P. Discontinuation of Trancopal (chlormezanone). fda. htm, last accessed on 16th December 2003. Pharmainformation Appetitzügler. html, last accessed on 15th December 2002. FDA FDA Announces Withdrawal of Fenfluramine and Dexphenfluramine (Fen-Phen). htm, last accessed on 5th March 2003. J. A. (2001) The underreporting of results and possible mechanisms of “negative” drug trials in patients with chronic heart failure. International Journal of Cardiology, 80, 19–27.

It was also prescribed to pregnant women as an antiemetic for morning sickness. By the end of 1961, it was found that thalidomide caused severe teratogenic effects, with strong fetal malformations like phocomelia (shortened or absent arms and legs). The drug was quickly withdrawn from the market, but in between 5000 and 12 000 deformed babies were born worldwide, with an unknown number of aborted fetuses. It was found that as little as a single dose of 50 mg, taken between day 35 and 49 after the last menstrual period, could produce the characteristic birth defects.

R. (1988) Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964–1985). British Journal of Clinical Pharmacology, 25, 387–396. 5 Kennedy, T. (1997) Managing the drug discovery/development interface. Drug Discovery Today, 2, 436–444. 6 WHO Amineptine (INN). doc, last accessed on 24th November 2003. 7 Amineptine (Survector): the Smart Tricyclic Antidepressant. BLTC. www. com, last accessed on 9th January 2007. 8 BIAM Amineptine Chlorhydrate. BIAM. org/www/Sub1826. html#Present, last accessed on 9th January 2007.

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Antitargets: Prediction and Prevention of Drug Side Effects by Roy J. Vaz, Thomas Klabunde, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers


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