Animal Models in Diabetes Research - download pdf or read online
By Hans-Georg Joost, Hadi Al-Hasani, Annette Schürmann
Detailing the most recent protocols for gaining knowledge of animal versions of diabetes, specially resistant teams of rodents reminiscent of the NOD mouse, and together with specialist recommendation on implementation, this can be a worthy new quantity within the tools in Molecular Biology sequence.
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7. Urine 24-h volume can be calculated by using the formula: Urine 24-h volume = Urine collection tubepost-study−Urine collection tubepre-study (empty). 8. In diabetic animals, urine may overflow the collection tube’s capacity and spill in the lower chamber of mouse cage. Larger containers can be used or the overflow urine should be collected carefully in an additional urine collection tube. Avoid transferring accidently feces into the collection tube. Determine volume of overflow urine by using above formula for urine volume.
Levels of albuminuria in FVB/NJ Akita mice suggest a moderate to severe susceptibility to renal injury resulting from type 1 diabetes, with 24-h urinary albumin excretion values being greater than the strains reported by Gurley and coworkers (8, 9). H. , unpublished 2 Diabetic Kidney Injury in Akita Mice 21 observation). Therefore, FVB/NJ Akita mice develop significant renal injury that may make this strain suitable for disease modeling. Together, these findings provide evidence for strong genetic modifiers influencing kidney phenotypes associated with diabetes, such as albuminuria and mesangial pathology.
3. Prevention and Reversal of Diabetes in the Diabetes-Prone Rat Model The BBDP rat model has historically been used in many studies to discover and evaluate potential treatments to prevent or reverse autoimmune human T1D. Administration of parenteral insulin and certain dietary modifications can prevent or delay diabetes onset in the BBDP rat (34, 35). Insulin gene therapy has been tested in BBDP rats using adenovirus to deliver a glucose-regulated insulin transgene (36). Diabetes in BBDP rats can also be prevented by intrathymic islets transplantation (37).
Animal Models in Diabetes Research by Hans-Georg Joost, Hadi Al-Hasani, Annette Schürmann