Download PDF by Martin Morad, Yuichiro J. Suzuki (auth.), Samuel Sideman,: Analytical and Quantitative Cardiology

By Martin Morad, Yuichiro J. Suzuki (auth.), Samuel Sideman, Rafael Beyar (eds.)

ISBN-10: 1461377315

ISBN-13: 9781461377313

ISBN-10: 1461559596

ISBN-13: 9781461559597

The 10th Henry Goldberg Workshop is a superb get together to bear in mind our ambitions and have a good time a few of our humble achievements. imaginative and prescient and love of our fellow guy are mixed right here to: 1) Foster interdisciplinary interplay among prime international scientists and medical cardiologists so one can establish lacking wisdom and catalyze new study rules; 2) relate easy microscale, molecular and subcellular phenomena to the worldwide clinically manifested cardiac functionality; three) follow conceptual modelling and quantitative research to raised discover, describe, and comprehend cardiac body structure; four) interpret on hand medical information and layout new revealing experiments; and five) improve foreign cooperation within the never-ending look for the secrets and techniques of lifestyles and their implication on cardiac pathophysiology. the 1st Goldberg Workshop, held in Haifa, in 1984, explored the interplay of mechanics, electric activation, perfusion and metabolism, emphasizing imaging within the scientific setting. the second one Workshop, in 1985, mentioned an identical parameters with a slant in the direction of the keep an eye on elements. The 3rd Goldberg Workshop, held within the united states at Rutgers collage, in 1986, highlighted the transformation of the microscale activation phenomena to macro scale job and function, bearing on electrophysiology, strength metabolism and cardiac mechanics. The fourth Goldberg Workshop persisted the hassle to explain a few of the parameters affecting cardiac functionality, with emphasis at the ischemic center. The 5th Workshop targeting the impact of the inhomogeneity of the cardiac muscle on its functionality. The 6th Workshop highlighted new imaging ideas which enable perception into the neighborhood and worldwide cardiac performance.

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30 I I ... 120nm ~~ 500ms Figure 4. A) The time course of the modulus of stiffness (MOD) and phase shift (cI» during diastole in the presence of 1 mM (circles) and 2 mM (squares) of [Ca2+ lo' The results are expressed as mean±sem; n=173, 18 muscles. 05. The time scale is expressed in % of diastolic interval. B) shows the time courses of SL of a muscle representative of Panel A, showing slight spontaneous motions of the sarcomeres (arrowhead) at 1 mM (upper trace) and 2 mM [Ca2+ lo (lower trace) during two consecutive diastoles.

A) Static elasticity (kp) and viscosity (1"]) were evaluated from the ratios dF/dSL and Fv/v, respectively in four trabeculae according to the method of De Tombe and Ter Keurs [1]. dF: maximal static elastic force [A:Fe trace (dotted line)]; LlSLe: sarcomere length variations at steady state; Fv: maximal viscous force calculated from the total force (solid line) minus clastic force predicted from a model of linear elastic element (dotted line) in parallel with the sarcomere. B) Time courses of ~ and 1"] determined in four trabeculae at different times of diastolic interval.

H. ter Keurs: Thank you for this question. We have also done the experiments at slightly lower frequencies and similar modules and phase shift behavior came out. At 500 Hz, we chose 500 Hz for a very simple, practical reason. Note that the length oscillations of the sarcomeres are always, in these experiments, less than 30 nm. That means we are working at about 1-2% sarcomere length; that creates a technical problem. We have chosen 500 Hz and a burst of around 30 ins in order to be able to extract the data accurately.

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Analytical and Quantitative Cardiology by Martin Morad, Yuichiro J. Suzuki (auth.), Samuel Sideman, Rafael Beyar (eds.)


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